Nasopharyngeal angiofibroma is a histologically benign but locally aggressive vascular tumor that grows in the back of the nasal cavity. It most commonly affects adolescent males and may grow into fissures of the. Nasoangiofibroma youth is a highly vascularized tumor almost exclusively male adolescents presentation. % represents % of head and. Angiofibroma nasofaring juvenile – Free download as PDF File .pdf), Text File . txt) or read online for free.

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Case 2 Case 2. Bony erosion of the nasal cavity, hard palate and pterygoid plates is also common. Loss of expression of GSTM 1 null genotype is seen in this tumor. Connective tissue was fibro-cellular with irregular pattern and plump fibroblasts [ Figure 6 ].

Surgery difficult to excise angioffibroma, preoperative embolization or antiandrogen therapy Chemotherapy or radiation therapy if advanced or aggressive. The tumor is primarily excised by external or endoscopic approach.

In this location, it produces widening of the pterygopalatine fossa, inferior orbital and pterygomaxillary fissures and bowing of the posterior wall of the maxillary antrum.

Nasopharyngeal angiofibroma

Overlying mucosa appeared normal. InFriedberg called it juvenile angiofibroma. The classification and clinical staging is relatively easy and helps to plan treatment and determine prognosis. Biological distinctions between juvenile nasopharyngeal angiofibroma and vascular malformation: Juvenile nasopharyngeal angiofibromas are benign but highly vascular xngiofibroma. These techniques help to establish the exact site, extension and relation of the tumor to the adjacent structures such angiofjbroma blood vessels and nerves.

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This would better define the treatment strategy. Open in a separate window. Intracranial extension can however occur.

Thus, early diagnosis, accurate staging and adequate treatment are essential in the management of angiofibroam lesion. Prognosis for nasopharyngeal angiofibroma is favorable. Check for errors and try again.

Markers of vascular differentiation, proliferation and tissue remodeling in juvenile nasopharyngeal angiofibromas. Numerous mast cells were noted with a minimal inflammatory cell infiltrate. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. The blood vessels are slit-like or dilated, organized in clusters and are of different calibers.

Ear Nose Throat J. Financial support and sponsorship Nil. A concise classification system and appropriate treatment options. Retrieved from ” https: Plain radiographs nasofarlng longer play a role in the workup of a suspected juvenile nasopharyngeal angiofibroma, however they may still be obtained in some instances during the assessment of nasal obstruction, or symptoms of sinus obstructions.

Fisch classification, however, is currently accepted.

Case 7 Case 7. DSA digital subtraction angiography of carotid artery to see the extension of tumors and feeding vessels. On palpation, the swelling was firm and nontender.

Juvenile nasopharyngeal angiofibroma | Radiology Reference Article |

Strayer; Emanuel Rubin Any lesion with this presentation may be confused with JNA. No encapsulation was noted [ Figure 4 ]. Genetic alterations in juvenile nasopharyngeal angiofibromas. Abstract Juvenile nasopharyngeal angiofibroma JNA is a rare benign tumor arising predominantly in the nasopharynx of adolescent males.

It is, as the name suggests, very vascular and a biopsy can sometimes be fatal. Nasopharyngeal angiofibroma also called juvenile nasopharyngeal angiofibroma [1] [2] is a histologically benign but locally aggressive vascular tumor that grows in the back of the nasal cavity. Imaging plays an important role in diagnosis, as biopsies should be avoided due to the risk of brisk hemorrhage, as well as staging.


However, these tumors are highly vascularized and grow rapidly. Medical angiogibroma and radiation therapy are only of historical interest.

Eventually, the tumor may invade the infratemporal fossa and the middle cranial fossa. However, since a vast majority of the cases do occur between 14 and 25 years of age, this term is retained.

A wait and watch policy with periodic imaging may thus postpone or eliminate the need for surgery and reduce morbidity. The presentation is typically with obstructive symptoms, epistaxisand chronic otomastoiditis due to obstruction of the Eustachian tube. MRI is superior to CT for detecting soft tissue extension of the tumor intracranially.

It most commonly affects adolescent males and may grow into fissures of the skull and may spread to adjacent structures. Olfactory neuroblastoma Olfactory neuroblastoma. The location and size of the tumor and feeding vessels are clearly demonstrated by this technique.

Nasopharyngeal angiofibroma – Wikipedia

W B Saunders Co. Although benign, it is a locally aggressive tumor and invades the surrounding tissues and even bone through pressure resorption. Angiography, although not essential, is often useful in both defining the feeding vessels as well as in preoperative embolisation.

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